ENTrigue Biologics

The Tutoplast® Tissue Process

The Tutoplast process is a unique processing method that results in tissue that is sterilized, yet retains its native structure and biological activity, making it safe for clinical use. The combination of stringent donor screening, laboratory testing, and validated processing ensures the safest, high-quality allografts.

The Tutoplast process preserves the natural collagen architecture of the graft tissue, providing an excellent matrix for host tissue regeneration and assimilation. It has been fully validated for preservation of tissue biomechanical properties and viral inactivation.

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Delipidization

Removes lipids and red and white blood cells.

Osmotic Treatment

Disrupts cell membranes to allow easier removal of cellular components.

Oxidative Treatment

Removes immunogenic structures, enveloped and non-enveloped viruses.

Solvent Treatment

Preserves the natural tissue matrix and allows for five-year shelf life.

Irradiation

Low-dose irradiation produces a terminally sterile graft, while preserving structural integrity.